The BBSRC and EPSRC have awarded £6.3m to the Manchester Centre for Integrative Systems Biology (MCISB) based at the Manchester Interdisciplinary Biocentre (MIB). The award is to pioneer the development of new experimental and computational technologies in Systems Biology, and their exploitation.
The MCISB is intended to provide a hub for cutting-edge systems biology research in the Manchester area, acting as a focal point for the creation of the necessary ideas and infrastructure, and for establishing new methods and routines.
The co-investigators in the project Professor Norman Paton, Professor Douglas Kell et al. It ran from May 2005 to April 2010.
Metabolomic Pathways
The Manchester Centre for Integrative Systems Biology is in the process of measuring the kinetic and binding constants associated with enzyme reactions in metabolic pathways in the yeast, Saccharomyces cerevisiae. Quantitative models of these metabolic pathways are being integrated with transcriptomic, proteomic and metabolomic data by workflows that have been constructed and enacted using Taverna.
Publications
A poster by Peter Li describing the systems biology workflows was presented at the International Conference of Systems Biology 2006 and he has written several publications about the work.
Many of the workflows make use of Systems Biology Markup Language (SBML) as described in the paper Automated manipulation of systems biology models using libSBML within Taverna workflows by Li et al.
An example workflow using SBML is available on myExperiment.
